АР13268737 "Development of technology for additive manufacturing of patient-specific metal implants with improved surface biocompatibility properties"

HomeResearchScientific and scientific-technical projects on grant and program-targeted financing ProjectsАР13268737 "Development of technology for additive manufacturing of patient-specific metal implants with improved surface biocompatibility properties"

АР13268737 "Development of technology for additive manufacturing of patient-specific metal implants with improved surface biocompatibility properties"

Азаматов Багдат Нурланович Name of the competition within which the project is being implemented: Grant funding of young scientists for the project «Zhas galym» for 2022-2024

Project Manager - Bagdat N. Azamatov, Ph.D.

Identifiers: Scopus Author ID: h-index in the Scopus database: 2. ORCID: https://orcid.org/0000-0001-6381-5846, Scopus Author ID: 57194540543.

Project Research Team

№	Full name	Project position	Identifiers (Scopus Author ID, Researcher ID, ORCID, if any) and links to related profiles
1.	Bagdat N. Azamatov	Chief Scientist	h-index in the Scopus database: 2. ORCID: https://orcid.org/0000-0001-6381-5846, Scopus Author ID: 57194540543
2.	Darya L. Alontseva	Chief Scientist	h-index in the Web of Science and Scopus databases: 6. ORCID: https://orcid.org/0000-0003-1472-0685, ResearcherID: H-1535-2014, Scopus Author ID: 6506822578

Project abstract

Worldwide, the priority for solving problems related to public health protection is the development of high-tech competitive technologies for the production of metal implants with biocompatible coatings. Currently, more than 5% of embedded implants are rejected by the patient's body due to the development of bone necrosis, which occurs when the implant surface is destroyed, deformed and metal particles penetrate into the surrounding tissues of the body or due to periprosthetic bacterial infections, which limits the use of modern implants. Therefore, the development of innovative coatings for medical implants is also in the spotlight.

The aim of the project is to develop the scientific foundations of additive manufacturing technology for patient-specific metal implants with improved surface biocompatibility properties and to obtain laboratory prototypes of orthopedic and dental implants of individual design.

Expected and achieved results of the project:

Year	The results obtained from the research. Publications (with links to them) and patents; information for potential users.
2022 year	An information and patent search based on the principle of search and analysis of scientific and technical information PRISMA (preferred reporting elements for systematic reviews and meta-analyses, prisma-statement.org ). First, the relevant publications on improving the biocompatibility of the implant surface, already available in the database of the authors of the project (part I), were selected. Secondly, a methodical search was conducted in Google Scholar for the period 2008-2022 by the keywords: "medical 3D printing" (Part II) and "additive manufacturing" (Part III). No links or articles on websites were considered, only original publications in peer-reviewed publications. Detailed information about the search results is provided in the report on the project in the form of a table that takes into account the number of full-text articles, patents and abstracts analyzed for each section and by keywords, and the number of works selected for citation for each section. New articles and patents presented in the open literature on the research topic were found and analyzed, and the issues of manufacturing implants using their three-dimensional models and new trends in technologies for increasing biocompatibility and bactericidal properties of the implant surface were considered. A review of modern literature showed the growing needs of society for orthopedic implants and allowed us to identify the main approaches and unresolved problems of the production of implants made by additive manufacturing (AM) that take root well in the human body. AM allows you to develop custom-designed implants with a porous surface, that is, to create better products that provide the best option for the patient. Another trend is thermal plasma spraying on the implant surface of multilayer biocompatible coatings with controlled structure and properties, with scientific justification of the composition, porosity, roughness of the coating and the choice of technological parameters of spraying, as well as robotization of the spraying process. Together, these two approaches make it possible to solve the problem of obtaining patient-specific metal implants with improved surface biocompatibility properties, convenient, which will not be rejected by the body and will help reduce the patient's recovery time. A literary review on the research topic has been written, including citations from 50 sources, a critical analysis of information from modern literary open sources, which presents the main scientific trends in the production of orthopedic implants, in order to identify the main problems and solutions to create well-engrafted implants. The review also analyzes the current trends in the use of metal and ceramic biocompatible materials for the creation of implants and their coatings, conclusions are drawn about the need for scientific justification of the choice of material, composition, porosity, roughness of the coating.
2023 year
2024 year

Year

The results obtained from the research.

Publications (with links to them) and patents; information for potential users.

2022 year

An information and patent search based on the principle of search and analysis of scientific and technical information PRISMA (preferred reporting elements for systematic reviews and meta-analyses, prisma-statement.org ). First, the relevant publications on improving the biocompatibility of the implant surface, already available in the database of the authors of the project (part I), were selected. Secondly, a methodical search was conducted in Google Scholar for the period 2008-2022 by the keywords: "medical 3D printing" (Part II) and "additive manufacturing" (Part III). No links or articles on websites were considered, only original publications in peer-reviewed publications. Detailed information about the search results is provided in the report on the project in the form of a table that takes into account the number of full-text articles, patents and abstracts analyzed for each section and by keywords, and the number of works selected for citation for each section.

New articles and patents presented in the open literature on the research topic were found and analyzed, and the issues of manufacturing implants using their three-dimensional models and new trends in technologies for increasing biocompatibility and bactericidal properties of the implant surface were considered. A review of modern literature showed the growing needs of society for orthopedic implants and allowed us to identify the main approaches and unresolved problems of the production of implants made by additive manufacturing (AM) that take root well in the human body. AM allows you to develop custom-designed implants with a porous surface, that is, to create better products that provide the best option for the patient. Another trend is thermal plasma spraying on the implant surface of multilayer biocompatible coatings with controlled structure and properties, with scientific justification of the composition, porosity, roughness of the coating and the choice of technological parameters of spraying, as well as robotization of the spraying process. Together, these two approaches make it possible to solve the problem of obtaining patient-specific metal implants with improved surface biocompatibility properties, convenient, which will not be rejected by the body and will help reduce the patient's recovery time.

A literary review on the research topic has been written, including citations from 50 sources, a critical analysis of information from modern literary open sources, which presents the main scientific trends in the production of orthopedic implants, in order to identify the main problems and solutions to create well-engrafted implants. The review also analyzes the current trends in the use of metal and ceramic biocompatible materials for the creation of implants and their coatings, conclusions are drawn about the need for scientific justification of the choice of material, composition, porosity, roughness of the coating.

2023 year

2024 year