Competition name: Competition for program-targeted funding for scientific and (or) scientific-technical programs for 2024-2026.

Project Manager: Aidar B. Kengesbekov, PhD, Acting Associate Professor.

 

Identifiers:

Project Research Team

№

Full name

Project position

Identifiers (Scopus Author ID, Researcher ID, ORCID, if any) and links to related profiles
1. Aidar B. Kengesbekov Project superviser, PhD Scopus ID: 57205287682 (https://www.scopus.com/authid/detail.uri?authorId=57205287682), 
Web of Science Researcher ID: AAJ-2006-2021,  
Google Scholar ID: qiSsE64AAAAJ&hl,  
ORCID: 0000-0002-5630-9467 https://orcid.org/0000-0002-5630-9467.
2. Layla B. Bayatanova LR Scopus Author ID: 55540404900 (https://www.scopus.com/authid/detail.uri?authorId=55540404900)
ResearcherID: ХКН-1113-2023, 
ORCID: 0000-0002-5630-4746 https://orcid.org/0000-0002-5630-4746.
3. Aksaule A. Mamaeva SR Scopus ID: 58064727000 https://www.scopus.com/authid/detail.uri?authorId=58064727000, 
ORCID: 0000-0002-9659-8152 https://orcid.org/0000-0002-9659-8152
4. Saule A. Abdulina SR Scopus Author ID: 56389550800 (https://www.scopus.com/authid/detail.uri?authorId=56389550800),  
Web of Science ResearcherID: ABC-5778-2021,  
ORCID https://orcid.org/0000-0001-6328-8652,  
Google Scholar ID автора: Nbg6V2cAAAAJ
5. Aidar K. Kenzhegulov  SR Scopus Author ID: 57210622996,  
Web of Science ResearcherID: AAD-1637-2020

Young scientists (under 40 + teaching staff (Students, undergraduates)

 

Full name

Project position

Identifiers (Scopus Author ID, Researcher ID, ORCID, if any) and links to related profiles

Note (Teaching staff, student, Master's student, doctoral student)
1 Daryn R. Baizhan R Scopus Author ID: 57214891142, (https://www.scopus.com/authid/detail.uri?authorId=57214891142),
Web of Science ResearcherID: AAC-3075-2022,
Google Scholar ID: o8AAAAJ,
ORCID 0000-0002-9105-3129(https://orcid.org/0000-0002-9105-3129).		 doctoral student
2 Nazerke Muktanova R Scopus Author ID: 58959124900 (https://www.scopus.com/authid/detail.uri?authorId=58959124900),
Web of Science Researcher ID: GSD-9094-2022,
ORCID:0000-0002-4823-6640 https://orcid.org/0000-0002-4823-6640.		 master
3 Zarina Y. Aringozhina R Scopus Author ID:
(https://www.scopus.com/authid/detail.uri?authorId=58639928600),
Researcher ID: IXL-4677-2023 https://www.researchgate.net/signup.SignUpRequest.html
Scholar ID: https://scholar.google.com/citations?hl=ru&user=jy3hazcAAAAJ&view_op=list_works&gmla=ABOlHixjY88IGGqDvQIGNcvpT-lHfsB4fRNNPCf8rIVTTsL4RAv41Nvkt-oYhxJLppE3bx3uzBCmg5Et3gajlB0mkCXGQ3sQ1_yZD1_m1aWN6A,
ORCID: 0009-0001-8428-4033.		 doctoral student
4 Ainur K. Seitkhanova R Scopus Author ID: 57211777742 https://www.scopus.com/authid/detail.uri?authorId=57211777742,
ORCID: https://orcid.org/0000-0001-8610-5492.		  
5 Zhanabai S. Turar JR   graduate student
6 Aynur Zh. Zhasulan JR Scopus ID 58837450200,
ORCID ID:0009-0001-5887-0135.		 doctoral student
7 Aynur Serikbaykyzy JR Web of Science ResearcherID: LRT-7969-2024,
ORCID: 0009-0005-7734-9512 https://orcid.org/0009-0005-7734-9512.		 doctoral student

Project abstract

This program is aimed at the development of innovative technologies and new materials for the creation of new generation domestic medical implants with high strength, corrosion resistance, biocompatibility and osteointegration. Within the framework of this program the methods of creation of biocompatible, bioactive coatings and modified surface for orthopedic, dental and vascular implants will be developed. Within the framework of the program complex experimental works will be carried out on development of methods for obtaining bioactive and biocompatible coatings and modification of bioinert titanium alloy for application in medical implants. The method of obtaining ultrafine-grained titanium alloy Ti-13Nb-13Zr for dental implants providing high biomechanical compatibility of the system "bone tissue-implant" will be developed. Biocomposite coatings based on TiO2-HAp (titanium dioxide-hydroxyapatite) will be created by methods of gas-thermal spraying (detonation spraying, HVOF and cold spraying) and micro-arc oxidation on the surface of coarse-grained Ti-13Nb-13Zr and ultrafine-grained Ti-13Nb-13Zr for orthopedic implants providing biocompatibility and promoting osteointegration. The technology of obtaining biocompatible thin-film coating based on TiOxNy for blood vessel prostheses will be developed, which is able to suppress platelet aggregation, minimize fibrin deposition, reduce inflammation and promote healing. Regularities of formation of the structural-phase state of TiO2-HAp-based composite coatings at gas-thermal spraying and micro-arc oxidation will be established. The interrelationships between the change of structural and phase characteristics of oxynitride coatings and deposition conditions will be studied. Biological studies of the coatings for cytotoxicity, bioactivity and in vitro antibacterial activity will be performed. Biotribocorrosion behavior of biocomposite coatings obtained by gas-thermal and magnetron sputtering methods as well as micro-arc oxidation will be studied. Prototypes of dental implants made of ultrafine-grained alloy Ti-13Nb-13Zr will be created and their fatigue behavior will be investigated. Also prototypes of implants made of ultrafine-grained titanium alloy with calcium-phosphate coating will be created. A clinical trial plan for the developed implants with biocomposite coatings will be developed. A business plan for the creation of a domestic enterprise for the production of medical implants will be developed. Within the framework of this program a special site for application of bioactive and biocompatible coatings on implants will be created on the basis of the scientific center "Protective and functional coatings" of D. Serikbayev VKTU. The implementation of the Program should ensure the fulfillment of strategically important state tasks aimed at the development of medicine, namely implantology. Creation of domestic implants of new generation, having competitive advantages over imported ones, will contribute to the development of medical sciences in the Republic of Kazakhstan and provide import substitution.

The expected scientific and socio-economic effect is caused by obtaining new fundamental knowledge for creation of new generation domestic implants based on ultrafine-grained titanium alloy and calcium-phosphate bio-coating with high strength, corrosion resistance, biocompatibility and osteointegration. The implementation of the results of this program will provide the competitiveness of the domestic implants. In addition, the results of the research contribute to the database on medical materials and thus will contribute to the implantology industry. Thus, the program is of great significance on a national and international scale.

The socio-economic effect of the program is reflected in the prospects of creating domestic high-quality bioimplants with a unique set of service properties much cheaper than imported ones. This program makes a social contribution through the expansion of knowledge, development of innovative technologies and training of highly qualified specialists in the field of materials engineering and bone implantology. Within the framework of the program implementation it is planned to prepare two doctoral theses (PhD) and four master's theses in the direction of "Technical Physics".

Target consumers of the obtained results: enterprises producing medical implants, as well as governmental bodies and organizations, research organizations and higher educational institutions.

Project Objective

Creation of domestic implants of new generation with biocomposite coatings with high strength, corrosion resistance, biocompatibility and osteointegration.

Expected and achieved results of the project:

Year

The results obtained from the research.
Publications (with links to them) and patents; information for potential users

2024

The effects of severe plastic deformation of Ti-13Nb-13Zr titanium alloy after combined ECAP/RS treatment will be investigated. The sequences of ECAP and RS stages with intermediate heat treatment will be determined. The number of ECAP/RS cycles will be optimized to achieve grain size less than 0.5 mkm. Microscopic studies (optical and electron microscopy) will be carried out to confirm ultrafine grain structure and homogeneity. Mechanical tests (strength, fatigue, elasticity) will be performed to evaluate the property improvements of the ultra-fine grained Ti-13Nb-13Zr alloy with an average grain size of less than 0.5 mkm.

The optimal modes (deformation temperature, pressure, number of revolutions) of severe plastic deformation of ultrafine-grained Ti-13Nb-13Zr alloy with average grain size less than 0.5 mkm will be selected. 

The role of pretreatment in enhancing the performance of biocomposite coatings will be identified. HAp-TiO2 biocomposite coatings will be obtained using a combined MDO technique followed by gas-thermal spraying (detonation spraying, HVOF and cold spraying) of calcium-phosphate ceramics based on hydroxyapatite. Comprehensive studies of theoretical and practical aspects of obtaining biocomposite coatings based on various combinations of non-metallic structures will be carried out.

2025

New data will be obtained on the influence of gas-thermal spraying modes: detonation spraying (percentage of barrel filling, gas mixture ratio); HVOF (gas pressure, powder feed rate) and cold spraying (spraying distance and temperature) on the phase and chemical composition of coatings, microstructure and pore size, adhesion and physical-mechanical properties of TiO2-HAp-based coatings.

Comprehensive experimental studies will be carried out to investigate the influence of deposition process parameters, such as discharge power and negative bias voltage, on phase formation, structure and nitrogen state in films grown by reactive magnetron sputtering.

The influence of micro-arc oxidation at direct and alternating currents using different electrolyte compositions (by changing the components and their concentration) will be investigated. The influence of technological parameters of MDO (voltage, current density, electrolyte flow rate, electrolyte temperature) on the structural-phase state of coatings will be studied.

2026

Features of formation of microstructure of oxynitride coatings depending on the parameters of the magnetron process will be investigated. The relationship between the change of structural and phase characteristics of coatings and deposition conditions will be established. On the basis of the obtained results a technical recommendation for the creation of biocompatible coatings based on titanium oxynitrides for blood vessel prostheses will be developed.
The optimal technological mode for producing HAp-TiO2 gradient coatings using several baths with different TiO2 concentrations will be determined. The role of gradient structure in improving the bond strength and cohesive properties of calcium-phosphate MDO coatings will be revealed.

Biological studies of the coatings for cytotoxicity, bioactivity and antibacterial activity by in vitro method will be carried out.

The biotribocorrosion behavior of biocomposite coatings obtained by gas-thermal and magnetron sputtering as well as micro-arc oxidation methods will be studied.

A clinical trial plan will be developed to evaluate the safety, efficacy and long-term suitability of new medical devices before they are introduced into widespread medical practice. Recommendations will be made for the introduction of new implants into medical practice.

A business plan for the creation of a domestic enterprise for the production of medical implants will be developed. The economic efficiency of the developed implants will be determined.

Infographics